MedGenome Study: Uncovering Parkinson's Genes in Young Indians

MedGenome, a leading global technology company in South Asia, and the Parkinson's Research Alliance of India (PRAI) conducted a study that identified rare and common variants based on the Polygenic Risk Score (PRS) in Young Onset. Found that can be found. Parkinson's disease (YOPD).

Through this collaboration, a pilot study targeting 100 people with Parkinson's disease were published in the July 2022 issue of the journal Advanced Biology. A new article published in the prestigious journal Movement Disorders confirms current knowledge and new findings about the genetics of Parkinson's disease.

This is the first study conducted in India to initiate a population-based genetic analysis of Parkinson's disease (YOPD) in the Indian population. The multi-center Pan India project, PAN-India Genetics of Young Onset Parkinson Disease (GOPI-YOPD), recruited 1000 patients through a network of specialist movement disorder centers/neurological clinics across India.

The research paper examines genetic variants associated with Parkinson's disease in an Indian population. This study confirms current findings in European populations and identifies essential genes in genes such as PRKN (13%), GBA, PINK1 and LRRK2. Many South Asian variants were found in the GBA gene, including p.Ser164Arg, through experimental research. This change is not seen in other populations. This opens the opportunity to conduct the first genetic test for Parkinson's disease in high-risk individuals and affected families in India. Physicians and geneticists can evaluate the results to guide patients to early intervention, reduced disease risk, and better treatment strategies