Dept of Revenue Adds 4 New Synthetic Opioids as Manufactured Drugs

India Pharma Outlook Team | Wednesday, 14 February 2024

 India Pharma Outlook Team

The revenue department has notified four synthetic opioid substances as synthetic drugs and three other substances as psychotropic substances under the Narcotic Drugs and Psychotropic Substances Act of 1985. The IRS has announced small quantities and amounts of marketing of these substances as part of imports, by the provisions of the law.

The Department, by notification, declared that the substances, salts and preparations of 2-Methyl-AP-237, Etazene, Etonitazepine and Protonitazepine and their preparations are medicines manufactured under the Act.

According to the Law, a narcotic is any substance made from coca, medicine, opium, poppy seed or any other narcotic or narcotic substance that the Central Government may notify.

2-Methyl-AP-237 is a new synthetic drug with actions similar to opioid agonists. According to the US Drug Enforcement Administration, this substance has appeared on the illegal artificial drug market since 2019, causing health problems and even death. A negative profit. This substance is an analog of buchinazine (AP-237), an opiate used for the treatment of cancer patients as a medicine in countries such as China.

Ethazene, also known as etodesnitazene, according to the World Health Organization (WHO), is a Schedule I drug (according to the 1961 United Nations Convention), such as clonitazene, etonitazene and isotonitazene, and its chemical composition with benzimidazole. - derivatives of synthetic opioids and pharmaceutical equivalents. (WHO). Opioid receptors are said to be more potent than morphine but less so than fentanyl.

According to the WHO, etonitazepine is a synthetic opiate derived from benzimidazole with chemical and pharmacological structures similar to List I drugs (according to the 1961 United Nations Convention), such as etonitazene. A critical review report published by the WHO in October 2022 stated that no medical use of these drugs was found.

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