Rejith P R, Correspondent, India Pharma Outlook
Lindy Biosciences, a protein therapeutic formulations firm, has announced a partnership with Novartis Pharmaceuticals to focus more on evolving drugs from Novartis to subcutaneous injections by using their micro classification suspension technology. The agreement will also be a crucial step in catering to the emerging needs for patient treatment options that can be self-managed at home.
There has been significant progress in this pharmaceutical landscape over the years. However, conventional drug formulation methods prioritize only safety and efficacy, whereas advanced medicine has a complete approach that meets the requirements of patient adherence, affordability, and efficiency. It is essential to have a clear understanding on how advance drug formaulations impacts the life of patients.
Patient-centered formulations play a crucial role in understanding the major needs of the patients which can help in enhancing treatment outcomes. These formulations are the key to improving the compliance of patients mainly with bigger ailments by prioritizing customized drug delivery systems, convenience in dosing, and taste masking. Besides, it becomes much easier for patients of all age groups to use customized formats in the form of liquid formulations and transdermal patches. Finally, by enhancing patient comfort and lowering the issues of drug regimens, the formulation ensures regular medicine use and thereby leads to better health results and quality of life.
For instance, Merck has implemented patient-centric strategies into the design formulation for diabetes and given more importance to understanding patient behavioral patterns to form formulations that improve ease of utilization, like a controlled release.
Gurpreet Singh, VP, MD (Integrated Safety), IQVIA says "The main approach to patient safety is to put the patient at the heart of all endeavours, as the patient is the subject of medication use, whether in clinical trials or pharmacovigilance"
The progress of Targeted Delivery Systems is seen as one of the most important discoveries in drug formulation. The system plays a pivotal role by making sure that the medicine is sent directly to the affected area, raising the drug's efficiency and lowering side effects. Besides, as the system primarily focuses on the affected area, it improves efficiency which can help in greater patient outcomes and high likely to recover faster from several ailments. In this modern era, liposomal formulations are being utilized for cancer treatments which enables chemotherapy medicine to be given directly to tumor cells, lowering harm to healthy tissues.
Novartis leverages Lutetium-177 dotatate which is an example of active targeting in radiopharmaceuticals. It aims somatostatin receptors in neuroendocrine tumors, exhibiting enhanced survival figures and treatment responses in contrast with conventional therapies.
Saransh Chaudhary, President, Global Critical Care, Venus Remedies Ltd and CEO, Venus Medicine Research Centre says "By incorporating patient-specific cells, researchers can tailor treatments to specific populations, augmenting therapeutic efficacy while mitigating the risk of adverse reactions"
By focusing on a stringent and fixed release of active pharmaceutical ingredients (API) for a longer period of time, sustained-release formulations can make a significant step in enhancing outcomes for patients. Also, it enables proper therapeutic drug levels in the bloodstream, removing the peaks that are associated with quick-release formulation. More importantly, sustained-release formulations significantly lower the need for instant dosing and improve patient adherence predominantly for severe health condition which needs longer medications. The other benefit is that the formulation also helps in reducing side effects because drug concentration becomes consistent, lowering the risk of overdose.
For example, Patheon makes use of SR technologies for lifecycle management to improve the market life of medicine and improve its clinical advantages. They deal with shifting drug formulations which can enhance patient adherence by lowering dosing frequency.
Dr. Kanav Kahol, CEO, DIVOC Health & Pink Tech Design says "Healthcare is one of the fastest growing sectors in India and it is relatively offering a lower priced treatment options that provide a great opportunity for the growth of various segments across the industry"
All in all, advanced drug formulation are inevitable in the field of healthcare as it will make considerable outcomes in improving treatments across several therapeutics. The formulations have to be leveraged by healthcare communities to the maximum to ensure that the patients receive benefits in disease recovery and lead healthier lives. A lot of research and developments are still occurring in drug formulation to come up with even more better comes. Although there may be complications with respect to cost and regulation, the future looks much more promising with innovations that will improve the way we treat ailments which will lead to better patient lives and the healthcare landscape.
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