| |NOVEMBER 20248MHRA SPEEDS UP GLOBAL POLIO ERADICATION WITH ADVANCED DETECTION METHODABBOTT'S TEAM-HF TRIAL AIMS EARLY INTERVENTION IN HIGH-RISK HEART FAILUREMHRA is showcasing efforts to train various WHO polio labs worldwide with an advanced molecular direct detection technique that can reduce detection times by 50 percent, aiding in the global push to eliminate polio and save lives.Working with Imperial College London, the University of Edinburgh, Biosurv International, and supported by the Bill and Melinda Gates Foundation, we have provided training to 25 countries in slightly more than a year on utilizing a method known as Direct Detection by Nanopore Sequencing (DDNS). This technique can accelerate the identification of polio outbreaks, preserving valuable time and money for public health agencies. This involves setting up training facilities in Pakistan, one of the remaining two countries where polio is still prevalent, as the number of cases has been on the rise this year.Detecting polio early is crucial, as the virus spreads quickly among a group of people. When polio is detected in a country, hundreds of individuals are likely already infected and can spread the virus to those who are not fully immunized. The virus replicates in the intestine after being transmitted through contact with contaminated food and water, typically infected feces, and can then infiltrate the nervous system to result in paralysis.The MHRA oversees the regulation of all medicines and medical devices in the UK to ensure their efficacy and safety. All of its efforts are supported by strong and evidence-based assessments to make sure that the rewards outweigh any potential dangers. POAbbott introduced a unique clinical trial aimed at enhancing results in patients with worsening heart failure who may benefit from advanced treatment choices. The TEAM-HF study aims to include a maximum of 850 participants from 75 locations globally and will utilize Abbott's CardioMEMS HF System to monitor pulmonary artery pressures (PAP). This will help in accurately pinpointing advanced heart failure patients with high mortality risk who may benefit from an early intervention with the HeartMate 3 left ventricular assist device (LVAD) for better outcomes.Heart failure is a gradual disease where the heart is unable to pump blood effectively, leading to signs like tiredness, difficulty breathing, and swollen ankles. "The goal of the TEAM-HF trial is simple in concept but critical to the future care of patients. We want to break down patient care silos, offering a unified effort to not only improve the diagnosis of advanced heart failure, but also enable rapid access to life saving heart pumps. This study aims to take the guess work out of deciding when a patient has reached the ideal time for LVAD implementation," said Jennifer Cowger, M.D., medical director of mechanical circulatory support and section head of the advanced heart failure program at Detroit-based Henry Ford Health, and one of the national co-principal investigators for the TEAM-HF trial. "Too many patients are not receiving timely access to this life-saving therapy and are needlessly dying of heart failure. The importance of patient access to multidisciplinary heart failure care is embodied in the trial acronym - TEAM-HF - and we feel this study will be instrumental in helping providers identify patients who may benefit from a heart pump earlier in their care journey." POTOP STORIES
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